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    Wyoming Technology Transfer and Research Products Center

    Dept. 3672

    1000 E. University Ave.

    Laramie, WY 82071

    Phone: (307) 766-2520

    Fax: (307) 766-2530

    Email: WyomingInvents@uwyo.edu

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    Method for Reducing Protein Misfolding in Cells

    UW ID: 12-001


    Description of Technology
     

              This technology provides a therapeutic method for reducing the levels of toxic mutant huntingtin protein present in an individual. This is accomplished by increasing expression or activity of selected quality control proteins in cells of Huntington‘s disease gene positive patients or those manifesting the disease. The technology also reduces protein misfolding in cells, promoting normal or improved cellular protein quality control by increasing expression of thiol transferases in affected cells effective for manipulating endoplasmic reticulum (ER) and cytosolic quality control. 


    Applications

              Huntington disease affects approximately 30,000 individuals in the United State and many more worldwide. This technology can be applied in a therapeutic setting, providing relief for those patients or potential persons affected by protein misfolding neurodegenerative diseases. Using this technology could regulate the huntingtin protein misfolds which accumulate in the brain and ultimately result in loss of brain functions. 


    Features & Benefits

              The benefits of this technology are the potential to help those who are or may become affected by a protein misfolding neurodegenerative disease. 

    Downloadable PDF: 12-001

    Inventors: 

    Fox, H. Jonathan


    Patent Status: 

    Utility Patent Issued


    Contact Us: 

    University of Wyoming Technology Transfer and Research Products Center 

    Dept. 3672

    1000 E. University Ave. 

    Laramie, WY 

    82071 

    Phone: 307-766-2520

    Fax: 307-766-2530

    Contact Us

    Wyoming Technology Transfer and Research Products Center

    Dept. 3672

    1000 E. University Ave.

    Laramie, WY 82071

    Phone: (307) 766-2520

    Fax: (307) 766-2530

    Email: WyomingInvents@uwyo.edu

    Find us on Instagram (Link opens a new window)Find us on Facebook (Link opens a new window)Find us on Twitter (Link opens a new window)Find us on LinkedIn (Link opens a new window)Find us on YouTube (Link opens a new window)